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ホーム > 研究業績

原著論文

2021年

　　#: Equal contribution

• Tabata E, Itoigawa A, Koinuma T, Tayama H, Kashimura A, Sakaguchi M, Matoska V, Bauer PO, Oyama F. Non-Insect-Based Diet Leads to Structural and Functional Changes of Acidic Chitinase in Carnivora. Molecular Biology and Evolution 2021 msab331. DOI:10.1093/molbev/msab331
• Toda Y#, Hayakawa T#, Itoigawa A, Kurihara Y, Nakagita T, Hayashi M, Ashino R, Melin AD, Ishimaru Y, Kawamura S, Imai H, Misaka T. (2021) Evolution of the primate glutamate taste sensor from a nucleotide sensor. Current Biology 31, 1–9, DOI:10.1016/j.cub.2021.08.002
• Inaba A, Arinaga A, Tanaka K, Endo T, Hayatsu N, Okazaki Y, Yamane T, Oishi Y, Imai H, Iwatsuki K. (2021) Interleukin-4 Promotes Tuft Cell Differentiation and Acetylcholine Production in Intestinal Organoids of Non-Human Primate. Int. J. Mol. Sci. 22, 7921 DOI:10.3390/ijms22157921
• Itoigawa A, Fierro F, Chaney ME, Lauterbur ME, Hayakawa T, Tosi AJ, Niv MY, Imai H. (2021) Lowered sensitivity of bitter taste receptors to β-glucosides in bamboo lemurs: An instance of parallel and adaptive functional decline in TAS2R16? Proc. R. Soc. B 288, 20210346. DOI:10.1098/rspb.2021.0346
• Hayashi M, Inaba A, Hakukawa M, Iwatsuki K, Imai H, Masuda K. (2021) Expression of TAS2R14 in the intestinal endocrine cells of non-human primates. Genes & Genomics 43, 259–267 DOI:10.1007/s13258-021-01054-7
• Inaba A, Kumaki S, Arinaga A, Tanaka K, Aihara E, Yamane T, Oishi Y, Imai H, Iwatsuki K. (2021) Generation of intestinal chemosensory cells from nonhuman primate organoids., Biochemical and Biophysical Research Commun. 536, 20-25 DOI:10.1016/j.bbrc.2020.12.044

2020年

　　#: Equal contribution

• Cody A. Ruiz, Morgan E Chaney, Masanori Imamura, Hiroo Imai, Anthony J. Tosi. Predicted structural differences of four fertility-related Y-chromosome proteins in Macaca mulatta, M. fascicularis, and their Indochinese hybrids. Proteins (2020) DOI:10.1002/prot.26021
• Okada S, Kuroki K, Ruiz CA, Tosi AJ, Imamura M. Molecular Histology of spermatogenesis in the Japanese macaque monkey (Macaca fuscata). Primates 2020 DOI:10.1007/s10329-020-00857-8
• Katayama K, Takeyama Y, Enomoto A, Imai H, Kandori H. Disruption of Hydrogen-Bond Network in Rhodopsin Mutations Cause Night Blindness. J. Mol. Biol. 2020 Aug 11:S0022-2836(20)30490-3. DOI:10.1016/j.jmb.2020.08.006.
• Nonaka Y, Hanai S, Katayama K, Imai H, Kandori H. Unique Retinal Binding Pocket of Primate Blue-Sensitive Visual Pigment. Biochemistry. 2020 Jul 21;59(28):2602-2607. DOI:10.1021/acs.biochem.0c00394.
• Shirasu M#, Ito S#, Itoigawa A, Hayakawa T, Kinoshita K, Munechika I, Imai H, Touhara K. Key male glandular odorants attracting female ring-tailed lemurs. Current Biology 30:11 pp2131-2138, 2020. DOI:10.1016/j.cub.2020.03.037
• Kitajima R#, Nakai R#, Imamura T, Kameda T, Kozuka D, Hirai H, Ito H, Imai H, *Imamura M#. Modeling of early neural development in vitro by direct neurosphere formation culture of chimpanzee induced pluripotent stem cells. Stem Cell Research 44: 101749 (2020) DOI:10.1016/j.scr.2020.101749
• Lin ZY-C#, Nakai R#, Hirai H, Kozuka D, Katayama S, Nakamura S, Okada S, Kitajima R, Imai H, Okano H, Imamura M#. Reprogramming of chimpanzee fibroblasts into a multipotent cancerous but not fully pluripotent state by transducing iPSC factors in 2i/LIF culture. Differentiation 112: 67-76 (2020) DOI:10.1016/j.diff.2020.01.002
• *Imai H, Hakukawa M, Hayashi M, Iwatsuki K, *Masuda, K. Expression of Bitter Taste Receptors in the Intestinal Cells of Non-Human Primates. Int. J. Mol. Sci. 2020, 21, 902. DOI:10.3390/ijms21030902
• Purba LHPS, Widayati KA, Suzuki-Hashido N, Itoigawa A, Hayakawa T, Nila S, Juliandi B, Suryobroto B, Imai H. Evolution of the bitter taste receptor TAS2R38 in colobines. Primates 2020;10.1007/s10329-020-00799-1, DOI:10.1007/s10329-020-00799-1. ReadOnly Link here

2019年

　　#: Equal contribution

• Bogutz, A.B., Brind’Amour, J., Kobayashi, H., Jensen K.N., Nakabayashi K., Imai H., Lorincz M. and Lefebvre L. Evolution of imprinting via lineage-specific insertion of retroviral promoters. Nat Commun 10, 5674 (2019) DOI:10.1038/s41467-019-13662-9
• Hirai H, Hirai Y, Udono T, Matsubayashi K, Tosi AJ, Koga A (2019) Structural variations of subterminal satellite blocks and their source mechanisms as inferred from the meiotic configurations of chimpanzee termini. Chromosome Res 27:321?332. PMID:31418128
• Hirai H, Go Y, Hirai Y, Rakotoarisoa G, Pamunkas S, Baicharoen S, Jahan I, Sajuthi D, Tosi AJ (2019) Considerable synteny and sequence similarity of primate chromosomal region VIIq31. Cytogenet Genome Res 158: 88-97. PMID:31220833
• K. Katayama, H. Imai, H. Kandori (2019) FTIR Study of S180A Mutant of Primate Red-sensitive Pigment. Chem. Lett. 48, 1142-1144. DOI:10.1246/cl.190458
• Kanthi Arum Widayati#, Xiaochan Yan#, Nami Suzuki-Hashido, Akihiro Itoigawa, Laurentia Henrieta Permita Sari Purba, Fahri Fahri, Yohey Terai, Bambang Suryobroto, Hiroo Imai. Functional divergence of the bitter taste receptor TAS2R38 in Sulawesi macaques. Ecol Evol 2019;00:1-17. DOI:10.1002/ece3.5557
• Itoigawa Akihiro, Hayakawa Takashi, Suzuki-Hashido Nami and Imai Hiroo. A natural point mutation in the bitter taste receptor TAS2R16 causes inverse agonism of arbutin in lemur gustation. 286 Proc. R. Soc. B (2019) PMID:31161904
• Nami Arakawa, Daisuke Utsumi, Kenzo Takahashi, Akiko Matsumoto-Oda, Atunga Nyachieo, Daniel Chai, Ngalla Jillani, Hiroo Imai, Yoko Satta, Yohey Terai. Expression changes of structural protein genes may contribute to adaptive skin characteristics specific to humans. Genome Biol. Evol. 13(3):613-628. 2019, PMID:30657921

2018年

• Matsumura K, Imai H, Go Y, Kusuhara M, Yamaguchi K, Shirai T, Ohshima K. Transcriptional activation of a chimeric retrogene PIPSL in a hominoid ancestor. Gene 678 (2018) 318-323, PMID:30096459
• Hayakawa T, Nathan SKSS, Stark DJ, Saldivar DAR, Sipangkui R, Goossens B, Tuuga A, Clauss M, Sawada A, Fukuda S, Imai H, Matsuda I. First report of foregut microbial community in proboscis monkeys: are diverse forests a reservoir for diverse microbiomes? Environ Microbiol Rep. 2018, PMID:29992728
• Katayama K, Furutani Y, Iwaki M, Fukuda T, Imai H, Kandori H (2018) "In situ" observation of the role of chloride ion binding to monkey green sensitive visual pigment by ATR-FTIR spectroscopy. Phys. Chem. Chem. Phys., 2018,20, 3381-3387, PMID:29297909
• Emiko Nishi, Nami Suzuki-Hashido, Takashi Hayakawa, Yamato Tsuji, Bambang Suryobroto, Hiroo Imai. Functional decline of sweet taste sensitivity of colobine monkeys. Primates (2018) PMID: 30191350
• Risako Nakai, Mari Ohnuki, Kota Kuroki, Haruka Ito, Hirohisa Hirai, Ryunosuke Kitajima, Toko Fujimoto, Masato Nakagawa, Wolfgang Enard, Masanori Imamura. Derivation of induced pluripotent stem cells in Japanese macaque (Macaca fuscata). Scientific Reports 8(1): 12187 (2018). PMID: 30111816
• Nishihara H, Stanyon R, Kusumi J, Hirai H, Koga A (2018) Evolutionary origin of OwlRep, a megasatellite DNA associated with adaptation of owl monkeys to nocturnal lifestyle. Genome Biology and Evolution,10 (1): 157-165. PMID: 29294004

2017年

• Jung YD, Lee HE, Jo A, Hiroo I, Cha HJ, Kim HS. Activity analysis of LTR12C as an effective regulatory element of the RAE1 gene. Gene 634 (2017) 22-28, PMID:28867566
• Anthony J Tosi, Hirohisa Hirai (2017) X chromosome introgression and recombination in the cephus group of Cercopithecus monkeys. Cytogenet Genome Res, PMID: 28977788
• Shoji Tatsumoto, Yasuhiro Go, Kentaro Fukuta, Hideki Noguchi, Takashi Hayakawa, Masaki Tomonaga, Hirohisa Hirai, Tetsuro Matsuzawa, Kiyokazu Agata and Asao Fujiyama (2017). Direct estimation of de novo mutation rates in a chimpanzee parent-offspring trio by ultra-deep whole genome sequencing. Scientific Reports, 7, 13561. PMID:29093469
• K. Katayama, Y. Nonaka, K. Tsutsui, H. Imai, H. Kandori. (2017) Spectral Tuning Mechanism of Primate Blue-Sensitive Visual Pigment Elucidated by FTIR Spectroscopy. Sci. Rep 7, 4904. PMID: 28687791
• K. Fukuda, Y. Inoguchi, K. Ichiyanagi, T. Ichiyanagi, Y. Go, M. Nagano, Y, Yanagawa, N. Takaesu, Y. Ohkawa, H. Imai, H. Sasaki (2017) Evolution of the sperm methylome of primates is associated with retrotransposon insertions and genome instability. Hum Mol Genet. 26, 3508-3519. PMID:28637190
• Y. Terai, R. Miyagi, M. Aibara, S. Mizoiri, H. Imai, T. Okitsu, A. Wada, S. Takahashi-Kariyazono, A. Sato, H. Tichy, H. Mrosso, S. Mzighani, N. Okada (2017) Visual adaptation in Lake Victoria cichlid fishes: depth-related variation of color and scotopic opsins in species from sand/mud bottoms BMC Evolutionary Biology 17, 200 DOI:10.1186/s12862-017-1040
• Akihiko Koga, Hideyuki Tanabe, Yuriko Hirai, Hiroo Imai, Masanori Imamura, Takao Oishi, Roscoe Stanyon, Hirohisa Hirai. Co-Opted Megasatellite DNA Drives Evolution of Secondary Night Vision in Azara’s OwlMonkey. Genome Biology and Evolution 9(7): 1963-1970 (2017) PMID: 28810713
• Hirata S, Hirai H, Nogami E, Morimura N, Udono T (2017) Chimpanzee down syndrome: a case study of trisomy 22 in a captive chimpanzee. Primates, 58:267-273. PMID:28220267
• Hirohisa Hirai, Yuriko Hirai, Mayumi Morimoto, Akihisa Kanoko, Yoshiro Kamanaka, Akihiko Kokga (2017) Night monkey hybrids exhibit de novo genomic and karyotypic alterations: the first such case in primates. Genome Biology and Evolution PMID: 28369492
• S. Bunlungsup, H. Imai, Y. Hamada, K. Matsudaira, S. Malaivijitnond. Mitochondrial DNA and two Y-chromosome genes of common long-tailed macaques (Macaca fascicularis fascicularis) throughout Thailand and vicinity. Am J Primatol 79, e22596 PMID: 27643851
• L. H. P. Purba, K. A. Widayati, K. Tsutsui, N. Suzuki-Hashido, T. Hayakawa, S. Nila, B. Suryobroto, H. Imai. Functional characterization of the TAS2R38 bitter taste receptor for phenylthiocarbamide in colobine monkeys. Biology Letters 13, 20160834. PMID: 28123110

総説

• 沼部令奈, 今井啓雄 (2021) 味覚の個人差と味覚受容体の遺伝子進化. 「アグリバイオ　味覚・食嗜好性研究の最前線」（北隆館）p.23-27
• 今井啓雄，林美沙 (2018) 動物の感覚とヒトとの比較. 「ひと・健康・未来 18 (2018)」
• 今井啓雄 (2017) 味覚受容体の進化と多様性. アグリバイオ 1, 89-91.
• 橋戸（鈴木）南美 (2016) 遺伝子からわかるサルの味覚「なきごえ」52: 3
• 今井啓雄，西栄美子 (2016) 味覚受容体タンパク質の進化と多様性「生物科学」67: 75-84
• 今井啓雄 (2015) サルの味覚を追ってフィールドに。「フィールドプラス」15: 22-23.
• 筒井圭, 今井啓雄 (2015)霊長類苦味受容体の機能的多様性 「比較生理生化学」32: 24-29.
• Imamura M, Hikabe O, Lin ZY, Okano H. (2014) Generation of Germ Cells In Vitro in the Era of Induced Pluripotent Stem Cells. Molecular Reproduction and Development 81: 2-19. PMID:23996404
• 今井啓雄，筒井圭 (2013) 霊長類苦味受容体の多様化「生体の科学」64: 430-431
• 早川卓志，今井啓雄 (2013) チンパンジーにおける苦味感覚の地域差と進化「生物の科学 遺伝」67: 418-424
• 今井啓雄，鈴木南美 (2013) 生息環境に応じた感覚受容体の機能進化「生物物理」53: 194-197. 日本生物物理学会

出版物

2021年

• 今井啓雄, 糸井川壮大. 味覚にかかわる遺伝子 「ヒトゲノム事典」（一色出版）p.263-264 分担執筆
• 糸井川壮大, 今井啓雄. 食にかかわる感覚の種差 「もっとよくわかる！食と栄養のサイエンス～食行動を司る生体恒常性維持システム～」（羊土社）p.35-46 分担執筆

2016年

• 鈴木-橋戸南美, 今井啓雄 霊長類の味覚 「 おいしさの科学的評価・測定法と応用展開」（シーエムシー出版）p.22-33.分担執筆
• 今井啓雄 (2016) 昼間視（明所視）　 「光と生命の事典」（朝倉書店）p.238-239.分担執筆

2013年

• Y. Shichida, T. Yamashita, H. Imai, T. Kishida (2013) Evolution and Senses: Opsins, Bitter Taste, Olfaction.

編集

• Hirai H, Imai H and Go Y (2012) Post-Genome Biology of primates, Primatology Monographs, Springer