JAPANESE TOP Message from the Director Information Faculty list Research Projects International Conference Entrance Exam Visitors Publication Job Vacancy International Partnerships Links Access HANDBOOK FOR INTERNATIONAL RESEARCHERS Map of Inuyama
BONOBO Chimpanzee "Ai" Crania photos Itani Jun'ichiro archives Guidelines for Care and Use of Nonhuman Primates(pdf) Study material catalogue/database Guideline for field research of non-human primates Primate Genome DB

Primate Research Institute, Kyoto University
Inuyama, Aichi 484-8506, JAPAN
TEL. +81-568-63-0567
(Administrative Office)
FAX. +81-568-63-0085

Copyright (c)
Primate Research Institute,
Kyoto University All rights reserved.



Identification of non-taster Japanese macaques for a specific bitter taste

N. Suzuki, T. Sugawara, A. Matsui, Y. Go, H. Hirai, and H. Imai

Bitter taste perception evolved as a key detection mechanism against the ingestion of bioactive substances, and is mediated by TAS2R gene family members in vertebrates. The most widely known and best studied bitter substance is phenylthiocarbamide (PTC), which is recognized by TAS2R38 and has a molecular structure similar to that of glucosinolates contained in Brassica plants. The "non-taster" phenotypic polymorphism (i.e., not sensitive to PTC-containing foods) has been identified in many primates, including humans. Here, we report genetic and behavioral evidence for the existence of "non-taster" Japanese macaques, which originated from a restricted region of Japan. Comparison of the sequences of the TAS2R38 gene of 333 Japanese and 55 rhesus macaques suggested that this genotype appeared after the divergence of these two species, independently of the appearance of human and chimpanzee "non-tasters". This finding might give a clue for elucidating the ecological, evolutionary, and neurobiological aspects of bitter taste perception of primates, as related to the plants that they sometimes use as foods in their habitats.

 Primates, Online first: http://www.ncbi.nlm.nih.gov/pubmed/20665225



Copyright(C) 2010 PRI (). All rights reserved.