Expression of taste signal transduction molecules in the cecum of common marmosets
Sae Gonda, Shuichi Matsumura, Shoichiro Saito, Yasuhiro Go, and Hiroo Imai
The extraoral presence of taste signal transduction proteins has recently been reported in rodents and humans. Here, we report the presence of these signal transduction proteins in the cecum of a non-human primate, the common marmoset. Quantitative RT-PCR data on the gene expression of taste signal transduction molecules (gustducin and TRPM5) in common marmosets suggested high expression in the cecum, which was not observed in other non-human primates. Immunohistochemical analysis confirmed the specific presence of gustducin and taste receptors in marmoset cecal cells. These results may relate to the specific feeding behavior of marmosets, which consume plant exudates, primarily gums.
Colocalization of taste-signaling molecules, gustducin (red) and TAS2Rs
in the marmoset cecum.
Quantitative RT-PCR analysis of gustducin in the gastrointestinal tract of
non-human primates. Plots show the expression level of gustducin mRNA in
newborn (A, n=2) and adult (C, n=2) Japanese macaques and in newborn (B,
n=4) and adult (D, n=3) common marmosets. Error bars indicate standard
errors calculated from three independent experiments on each individual.
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