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Chromosome Dynamics Regulating Genomic Dispersion and Alteration of Nucleolus Organizer Regions (NORs).
Hirohisa Hirai
Review

The nucleolus organizer regions (NORs) demonstrate differences in genomic dispersion and transcriptional activity among all organisms. Its mechanism is still obscure. I postulated molecular effect, "affinity rules", that such differences stem from distinct genomic structures and their interactions from our own observations in primates and ants. It was extrapolated from affinity/non-affinity system of genome structures in the vicinity of NORs and the chromosomal configurations of meiotic prophase. I propose that there are limited and non-limited genomic dispersion systems that result from genomic affinity rules, inducing specific chromosomal configurations that are related to NORs.

Bibliographic information

Cells 2020, 9 (4), 971
https://doi.org/10.3390/cells9040971
2020/04/16 Primate Research Institute