演者：Prof. Svante Pääbo
問合せ先：今井啓雄（imai_at_pri.kyoto-u.ac.jp : atを@に変換してください）
Mapping tameness genes in a rat model for animal domestication
Frank W. Albert and Svante Pääbo
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
Domestication of animals has played an important role in the development of agricultural human societies. While many studies have investigated when, where, and how often humans have domesticated wild animals, little is known about what functional variants were selected. Specifically, all domestic animals share the trait of tameness, i.e. they tolerate human presence and handling. The genetic basis for tameness remains unknown.
In order to uncover the genetic basis for tameness, we are studying two lines of wild-caught rats (Rattus norvegicus) that were selected for more than 60 generations for reduced and enhanced aggressive and fearful behavior towards humans. Today, tame rats tolerate being touched and handled. Aggressive rats flee from and attack an approaching human hand.
We have performed a quantitative trait locus (QTL) mapping in an F2 intercross design. We have obtained data from >700 F2 animals, on behavioral, morphological and serological measures as well as >200 genetic markers and discovered a highly significant QTL influencing tameness, as well as an epistatic network of five loci that influence tameness and aggression in the rats. We are currently pursuing several fine-mapping strategies, which will be described.