Young-A Lee

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(過去のメンバー、最終更新2014/3/31)

CONTACT

Kyoto University Primate Research Institute
Cognition & Learning Section
41-2 Kanrin, Inuyama, Aichi
484-8506, Japan
Phone/Fax: +81(568)63-0551

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ACADEMIC BACKGROUND

2005–2008
Graduate study, PhD
Pharmaceutical Sciences, University of Toyama Institute of Natural Medicine (Toyama, Japan)

2003–2005
Graduate study, MSc
Food Science and Nutrition, Pusan National University (Pusan, Korea)

1996–2000
Undergraduate study, BSc
Food Science and Nutrition, Pusan National University (Pusan, South Korea)

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WORK EXPERIENCE

2013–Present
Postdoctoral Fellow
Kyoto University Primate Research Institute (Aichi, Japan)

2012–2013
Postdoctoral Fellow
University of Toyama Institute of Natural Medicine (Toyama, Japan)

2009–2012
Postdoctoral Fellow
Department of Psychiatry, McGill University (Montreal, QC, Canada)

2005
Visiting Researcher
Pharmaceutical Sciences, University of Toyama Institute of Natural Medicine (Toyama, Japan)

2004
Visiting Researcher
Pharmaceutical Sciences, University of Toyama Institute of Natural Medicine (Toyama, Japan)

2000–2003
Nutritionist
ECMD Co. Ltd. (Pusan, South Korea)

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AWARDS AND DISTINCTIONS

2012
RI-MUHC Postdoctoral Fellowship (Resigned due to moving to another institute)
Research Institute – McGill University Health Centre

2010
RI-MUHC Postdoctoral Fellowship
Research Institute – McGill University Health Centre

2007
Doctoral Research Award
Rotary Yoneyama Memorial Foundation

2006
Doctoral Research Award
Tsukushi Fellowship & Research Foundation

2006
Doctoral Research Award
Japan Student Services Organization

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RESEARCH AND SCHOLARLY ACTIVITY

(PEER-REVIEWED ARTICLES)

18. Tohda, C., Lee, Y. A., Goto, Y., Nemere, I. (2013) Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D3-MARRS. Scientific Reports, 3: 3395.

17. Lee,Y. A. and Goto, Y. (2013) Reconsideration of animal models of schizophrenia and other psychiatric disorders with evolutionary perspective. Medical Hypotheses, 81: 1120-1126..

16. Lee, Y. A. and Goto, Y. (2013) Habenula and ADHD: Convergence on Time. Neuroscience & Biobehavioral Reviews, 37: 1801-1809.

15. Lee, Y.A. and Goto, Y. (2013) Prenatal and postnatal stress interaction: environmental adaptation hypothesis. Journal of Physiology-Paris, 107: 483-492.

14. Goto, Y. and Lee, Y.A. (2011) Is schizophrenia developmental adaptation to environmental menaces? Medical Hypotheses, 77: 756-762.

13. Lee, Y.A. and Goto, Y. (2011) Chronic stress modulation of prefrontal cortical NMDA receptor expression disrupts limbic structures-prefrontal cortical interaction. European Journal of Neuroscience, 34: 426-436.

12. Lee, Y.A. and Goto, Y. (2011) Neurodevelopmental disruption of cortico-striatal function caused by degeneration of habenula neurons. PLoS ONE, 6: e19450

11. Lee, Y.A., Poirier, P., Otani, S., and Goto, Y. (2011) Dorsal-ventral distinction of chronic stress-induced electrophysiological alterations in the rat medial prefrontal cortex. Neuroscience, 183: 108-120

10. Yokozawa, T., Lee, Y. A., Cho, E. J., Matsumoto, K., Park, C. H., and Shibahara, N. (2011) Anti-aging effects of oligomeric proanthocyanidins isolated from persimmon fruits. Drug Discoveries & Therapeutics, 5: 109-118.

9. Lee, Y.A., Cho, E. J., and Yokozawa, T. (2010) Oligometric proanthocyanidins improve and enhance phosphorylation of vascular endothelial growth factor receptor-2 in senescence-accelerated mouse prone/8. British Journal of Nutrition, 103: 479-489.

8. Yokozawa, T., Lee, Y.A., Zhao, Q., Matsumoto, K., and Cho, E.J. (2009) Persimmon oligometric proanthocyanidins extend life span of senescence-accelerated mice. Journal of Medicinal Food, 12: 1199-1205.

7. Lee, Y.A., Cho, E. J., and Yokozawa, T. (2008) Effects of proanthocyanidin preparations on hyperlipidemia and other biomarkers in mouse model of type 2 diabetes. Journal of Agricultural and Food Chemistry, 56: 7781-7789.

6. Lee, Y.A., Cho, E. J., and Yokozawa, T. (2008) Protective effect of persimmon (Dispyros Kaki) peel proanthocyanidin against oxidative damage under H2O2-induced cellular senescence. Biological & Pharmaceutical Bulletin, 31: 1265-1269.

5. Lee, Y.A., Kim, Y. J., Cho, E. J., and Yokozawa, T. (2007) Ameliorative effects of proanthocyanidin on oxidative stress and inflammation in streptozotocin-induced diabetic rats. Journal of Agricultural and Food Chemistry, 55: 9395-9400.

4. Lee, Y.A., Cho, E. J., Tanaka, T., and Yokozawa, T. (2007) Inhibitory activities of proanthocyanidins from persimmon against oxidative stress and digestive enzymes related to diabetes. Journal of Nutritional Science and Vitaminology, 53: 287-292.

3. Yokozawa, T., Kim, Y. A., Kim, H. Y., Lee, Y.A., and Nonaka, G. (2007) Protective effect of persimmon peel polyphenol against high glucose-induced oxidative stress in LLC-PK(1) cells. Food and Chemical Toxicology, 45: 1979-1987.

2. Cho, E. J., Lee, Y.A., Yoo, H. H., and Yokozawa, T. (2006) Protective effects of broccoli (Brassica oleracea) against oxidative damage in vitro and in vivo. Journal of Nutritional Science and Vitaminology, 52: 437-444.

1. Piao, X. L., Kim, H. Y., Yokozawa, T., Lee, Y.A., Piao, X. S., and Cho, E. J. (2005) Protective effects of broccoli (Brassica oleracea) and its active components against radical-induced oxidative damage. Journal of Nutritional Science and Vitaminology, 51: 142-147.

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(ABSTRACTS FOR CONFERENCE PRESENTATION)

24. Goto, Y., Lee, Y.A., and Takita, M. (2013) The habenula in the pathogenesis of ADHD. 36th Annual Meeting of the Japan Neuroscience Society, S1-1-5.

23. Lee, Y.A. and Goto, Y. (2013) Prenatal stress-induced neurodevelopmental alterations as environmental adaptation. 36th Annual Meeting of the Japan Neuroscience Society, P1-1-189.

22. Takita, M., Lee, Y.A., and Goto, Y. (2013) The developmental changes in correlations between prefrontal dopamine/serotonin release and open-field behaviors with neonatal habenula lesion. 36th Annual Meeting of the Japan Neuroscience Society, P1-1-188.

21. Takita, M., Lee, Y.A., and Goto, Y. (2013) The developmental changes in prefrontal cortical dopamine and serotonin release with neonatal habenula lesion. 90th Annual Meeting of the Physiological Society of Japan, 3PK-176.

20. Takita, M., Lee, Y.A., and Goto, Y. (2011) The effects of neonatal habenula lesion on prefrontal dopamine and serotonin release in juvenile rats. 89th Annual Meeting of the Physiological Society of Japan, 3PJ-167.

19. Lee, Y.A. and Goto, Y. (2011) Histamine H3 antagonist improves ADHD-like behavioral and electrophysiological changes caused by neonatal habenula lesion. 776.04, Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience Online

18. Lee, Y.A., Yoon, H., and Goto, Y. (2010) Neonatal treatment of nicotine into the habenula induces ADHD-like behavioral alterations. 871.12, Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience Online

17. Goto, Y., and Lee, Y.A. (2010) Alterations of spike firing in the prefrontal cortex of the animal model of ADHD with neonatal habenula lesion. 871.10, Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience Online

16. Lee, Y.A. and Goto, Y. (2010) Neonatal habenula lesion as a novel animal model of ADHD. P46, 43rd Winter Conference on Brain Research, Breckenridge, CO

15. Poirier, P., Lee, Y.A., and Goto, Y. (2009) Correlation between tyrosine hydroxylase immunoreactivity in the prefrontal cortex and working memory and its alteration with chronic stress. 282.7, Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience Online

14. Lee, Y.A., Mahar, I., and Goto, Y. (2009) Neonatal habenula lesion causes behavioral and physiological alterations resembling ADHD. 636.5, Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience Online

13. Lee, Y.A., Cho, E. J., and Yokozawa, T. (2008) Improved Effects and Its Mechanism of Oligomeric Proanthocyanidins Isolated from Persimmon against Memory Impairment. The Korean Society of Food Science and Nutrition. Jeju. South Korea.

12. Lee, Y.A. and Yokozawa, T. (2008) Anti-Aging Effects of Oligomeric Proanthocyanidin Isolated from Persimmon Fruits. The Kidney and Free Radical Research Association. Osaka, Japan.

11. Cho, E. J., Lee, Y.A., Okamoto, T., and Yokozawa, T. (2008) Anti-aging activity of Kangen-karyu in human fibroblast cells. Medical and Pharmaceutical Society for WAKAN-YAKU. Osaka. Japan.

10. Lee, Y.A., Cho, E. J., and Yokozawa, T. (2008) Anti-Aging Effects of Oligomeric Proanthocyanidin Isolated from Persimmon Fruits. The 12th International Conference on Oriental Medicine of Dong-Eui & Daegu Haany University. Pusan, South Korea.

9. Lee, Y.A., Cho, E. J., Tanaka, T., Thoda, C., and Yokozawa, T. (2008) Influence of Persimmon Polyphenolic Oligomers on Memory Impairment in Senescence Accelerated Mouse Prone 8 (SAMP8). The Pharmaceutical Society of Japan. Yokohama, Japan.

8. Lee, Y.A., Cho, E. J., Tanaka, T., and Yokozawa, T. (2008) Investigation of Efficiency in Type 2 Diabetic Model of Persimmon Polyphenols. The Pharmaceutical Society of Japan. Yokohama, Japan.

7. Lee, Y.A., Cho, E. J., and Yokozawa, T. (2007) Protective effects of proanthocyanidin from persimmon peel on oxidative stress and inflammation in diabetic rats. The Korean Nutrition Society. Seoul, South Korea.

6. Lee, Y.A., Cho, E. J., Kim, H. Y., and Yokozawa, T. (2006) Anti-aging effects of persimmon (Dispyros Kaki) peel on H2O2-induced premature senescence. The Korean Society of Food Science and Nutrition. Gyeongju, South Korea. 

5. Lee, Y.A., Satoh, A., Cho, E. J., and Yokozawa, T. (2006) Protective effects of proanthocyanidin isolated from persimmon peel in streptozotocin-induced diabetic rats. The Kidney and Free Radical Research Association. Tukuba, Japan.

4. Lee, Y.A., Satoh, A., Cho, E. J., and Yokozawa, T. (2006) The mechanisms underlying anti-aging activity of the persimmon polyphenols in human fibroblast cells. Japan Society for Biomedical Gerontology. Nagasaki, Japan.

3. Lee, Y.A., Satoh, A., Cho, E. J., Tanaka, T., and Yokozawa, T. (2006) Protective effect of persimmon  (Dispyros Kaki) peel proanthocyanidin against oxidative damage under H2O2-induced cellular senescence. The Pharmaceutical Society of Japan, Sendai, Japan.

2. Lee, Y.A., Cho, E. J., Satoh, A., and Yokozawa, T. (2005) Protective effects against diabetic oxidative stress of BuOH fraction from broccoli flower  (Brassica oleracea). Japanese Society of Lipid Peroxide and Free Radical Research, Kobe, Japan.

1. Lee, Y.A., and Cho, E. J. (2004) Protective effects against radical-induced oxidative damages of broccoli   (Brassica oleracea) and its active components. The Korean Society of Food Science and Nutrition. Jeju, South Korea.

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(INVITED LECTURES) 

2012
3rd International Symposium on Prefrontal Cortex (Kyoto, Japan)

2010
University of Paris VI (Paris, France)

2009
Pukyong National University (Pusan, South Korea)

2009
Pusan National University (Pusan, South Korea)

2008
12th International Conference on Oriental Medicine of Dong-Eui & Daegu Haany University (Pusan, South Korea)

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(RESEARCH GRANTS)

2011–2012
Collaborative Research Grant
Agency: University of Toyama Institute of Natural Medicine
Co-PI: Young-A Lee, Yukiori Goto, Chihiro Tohda
Total Direct Cost: JPY¥800,000
Title: Research on the effects of diosgenin on memory function.

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SERVICES AND OTHER APPOINTMENTS 

(SCIENTIFIC ORGANIZATIONS)

2010–Present
Member, Society for Neuroscience

2010–Present
Foreign Member, Japan Neuroscience Society

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(JOURNAL REVIEWS)

Hippocampus

International Journal of Neuropsychopharmacology

Progress in Neuro-Psychopharmacology & Biological Psychiatry