HOPE report


Invitation: Roscoe Stanyon
Presentation in HOPE Symposium 2007: Primate Origins of Human Evolution

Report:Hirai Hirohisa

Date:2007/11/15 - 2007/11/21

In the hope symposium, he gave a presentation entitled " The Cytogenetics of the Macaque Genome: Origins, Marker order and Neocentromeres". He talked about the genome mapping using comparative chromosome painting or Zoo-FISH of the Japanese macaque (Macaca fuscata), efficiencies of chromosome painting to detect inter-chromosomal rearranngments (translocations) between species, chromosomal syntenies of all living primates, usefulness of FISH mapping of BACs to detect intra-chromosomal rearrangements (inversions), neocentromeres and define breakpoints. He showed from the analyses that between humans and macaques a total of 14 neocentomeres were found: 9 in the macaque and 5 in the human lineage and the sites of evolutionary neocentromere or ancient inactivated centromeres. He suggested that the study of evolutionary chromosomal rearrangements could shed light on chromosomal rearrangements in disease. Afterward, several questions from the floor were given and fruitful discussion on mechanism and evolution of the neocentromeres between macaques and human lineages. He actively gave many questions in other sessions (paleontology of macaques, social ecology of gibbons, and conservation of gibbons) and suggested significant perspectives with knowledge learned in anthropology.

Roscoe Stanyon

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