ENGLISH トップ 所長挨拶 概要 教員一覧 研究分野・施設 共同利用・共同研究 大型プロジェクト 国際集会 教育,入試 広報,公開行事,年報 新着論文,出版 教員,職員公募 国際共同事業 霊長類研究基金 リンク アクセス HANDBOOK FOR INTERNATIONAL RESEARCHERS Map of Inuyama サイトマップ
コラム・連載 質疑応答コーナー ボノボ チンパンジー「アイ」 頭蓋骨画像データベース 霊長類学文献データベース サル類の飼育管理及び使用に関する指針 Study material catalogue/database 野生霊長類研究ガイドライン 霊長類ゲノムデータベース 写真アーカイヴ ビデオアーカイヴ

TEL. 0568-63-0567(大代表)
FAX. 0568-63-0085

Copyright (c)
Primate Research Institute,
Kyoto University All rights reserved.



Higher-order repeat structure in alpha satellite DNA is an attribute of hominoids rather than hominids



Journal of Human Genetics (2013): Advance online publication. DOI: 10.1038/jhg.2013.87

Alpha satellite DNA (AS), a major DNA component of primate centromeres, is composed of a tandem array of repeat units of approximately 170 bp. The AS of hominids (family Hominidae; humans and great apes) includes sequences organized into higher-order repeat (HOR) structures, with a periodic appearance of multiple copies of the basic repeat units. Here, we identified an HOR in AS of the siamang, a small ape phylogenetically distinct from hominids but included in hominoids (superfamily Hominoidea). We sequenced long stretches of genomic DNA, and found a repetition of blocks consisting of six and four basic repeat units. Thus, AS organization into HOR is an attribute of hominoids, rather than, as currently postulated, hominids. In addition to centromeres, siamangs carry AS in terminal heterochromatin blocks, and it cannot be determined at present whether these HOR-containing AS sequences originate from the centromere or from the terminal heterochromatin. Even if the latter is the case, these sequences might affect the composition of centromeric AS by being transferred to the centromere.


Copyright(C) 2012 PRI ().