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Primate Research Institute, Kyoto University
Hepatocellular carcinoma with intracranial metastasis in a Japanese macaque (Macaca fuscata)
Takako Miyabe-Nishiwaki, Akihiro Hirata, Akihisa Kaneko, Akiyo Ishigami, Yoko Miyamoto, Atsushi Yamanaka, Keishi Owaki, Hiroki Sakai, Tokuma Yanai and Juri Suzuki
A 23-year-old male Japanese macaque (Macaca fuscata) showed left ptosis, which progressed to exophthalmos.
Methods The macaque underwent a clinical examination, CT and MRI, and was euthanized. Necropsy and histopathological examination were performed after euthanasia.
The CT revealed and MRI confirmed an intracranial mass at the skull base with orbital extension. At necropsy, there were a large hepatic mass and an intracranial mass compressing the left temporal lobe of the brain. Histopathological and immunohistological examinations revealed that the masses were hepatocellular carcinoma (HCC) and a metastatic lesion. In both the primary and metastatic lesions, neoplastic hepatocytes were arranged mainly in a trabecular pattern. Immunohistochemically, the tumor cells were positive for cytokeratin (AE1/AE3 and CAM5.2) and Hepatocyte Paraffin 1 and negative for cytokeratin 7 and 20 and vimentin.
To our knowledge, this is the first case report of HCC with intracranial metastasis in a macaque.
Journal of Medical Primatology
Article DOI: 10.1111/jmp.12261
2017/04/07 Primate Research Institute