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Primate Research Institute, Kyoto University
Direct estimation of de novo mutation rates in a chimpanzee parent-offspring trio by ultra-deep whole genome sequencing.
Shoji Tatsumoto, Yasuhiro Go, Kentaro Fukuta, Hideki Noguchi, Takashi Hayakawa, Masaki Tomonaga, Hirohisa Hirai, Tetsuro Matsuzawa, Kiyokazu Agata & Asao Fujiyama
We determined the unprecedented amount of whole genome sequences from a chimpanzee parent-offspring trio and disclosed the precise mutation rates and modes through the transmission of genomes from parents to offspring. Through the transmission of genomes, very rare but a certain frequency of de novo (new) mutations have occurred (illustrated in the figure as 'T' in the father chromosome substitute to 'C' in the inherited chromosome in offspring). About 75% of this type of mutation has occurred in the paternally-derived germline cells (male-biased mutation).
Scientific Reports 7, Article number: 13561 (2017)
2017/11/02 Primate Research Institute