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Takako Miyabe-Nishiwaki


  • Current position:
    Assistant Professor, Center for Model Human Evolution Research, Primate Research Institute, Kyoto University
  • Education:
    PhD - Veterinary Science, University of Wisconsin, 2005
    MS - Veterinary Science, University of Wisconsin, 2003
    DVM - The Ministry of Agriculture and Fishery, Japan, 2001
    BS - The University of Tokyo, Japan (Veterinary Medicine), 2001

Research Interest

1) Anesthesia and Analgesia in non-human primates

  • Population pharmacokinetics and pharmacodynamics of propofol in Japanese macaques
  • Evaluation of pain in macaques

2) Spontaneous diseases in non-human primates

3) Collaborative studies

  • Gibbon project
  • Infectious diseases in chimpanzees
  • Oral health in chimpanzees

Recent Publications

Miyabe-Nishiwaki T, Kaneko T, Sakai T, Kaneko A, Watanabe A, et al. (2014) Intracranial arachnoid cysts in a chimpanzee (Pan troglodytes). Primates 55: 7-12.

Sakai T, Matsui M, Mikami A, Malkova L, Hamada Y, et al. (2013) Developmental patterns of chimpanzee cerebral tissues provide important clues for understanding the remarkable enlargement of the human brain. Proc Biol Sci 280: 20122398.

Okamoto M, Imai S, Miyanohara M, Saito W, Momoi Y, et al. (2013) Streptococcus troglodytae sp. nov., from the chimpanzee oral cavity. Int J Syst Evol Microbiol 63: 418-422.

Miyabe-Nishiwaki T, Masui K, Kaneko A, Nishiwaki K, Nishio T, et al. (2013) Evaluation of the predictive performance of a pharmacokinetic model for propofol in Japanese macaques (Macaca fuscata fuscata). J Vet Pharmacol Ther 36: 169-173.

Kooriyama T, Okamoto M, Yoshida T, Nishida T, Tsubota T, et al. (2013) Epidemiological study of zoonoses derived from humans in captive chimpanzees. Primates 54: 89-98.

Kaneko T, Sakai T, Miyabe-Nishiwaki T, Tomonaga M (2013) A case of naturally occurring visual field loss in a chimpanzee with an arachnoid cyst. Neuropsychologia 51: 2856-2862.

MacIntosh AJ, Huffman M, Nishiwaki K, Miyabe-Nishiwaki T (2012) Urological Screening of a Wild Group of Japanese Macaques (Macaca fuscata yakui): Investigating Trends in Nutrition and Health. International Journal of Primatology 33: 460-478.

Sakai T, Mikami A, Tomonaga M, Matsui M, Suzuki J, et al. (2011) Differential prefrontal white matter development in chimpanzees and humans. Curr Biol 21: 1397-1402.

Miyabe-Nishiwaki T, Masui K, Kaneko A, Nishiwaki K, Shimbo E, et al. (2010) Hypnotic effects and pharmacokinetics of a single bolus dose of propofol in Japanese macaques (Macaca fuscata fuscata). [corrected]. Vet Anaesth Analg 37: 501-510.

Miyabe-Nishiwaki T, Kaneko A, Nishiwaki K, Watanabe A, Watanabe S, et al. (2010) Tetraparesis resembling acute transverse myelitis in a captive chimpanzee (Pan troglodytes): long-term care and recovery. J Med Primatol 39: 336-346.

Nishio T, Suzuki R, Tsukada Y, Kanazawa H, Okano T, et al. (2009) Aqueous chromatographic system for the quantification of propofol in biological fluids using a temperature-responsive polymer modified stationary phase. J Chromatogr A 1216: 7427-7432.

Miletic G, Driver AM, Miyabe-Nishiwaki T, Miletic V (2009) Early changes in Homer1 proteins in the spinal dorsal horn are associated with loose ligation of the rat sciatic nerve. Anesth Analg 109: 2000-2007.

Miyabe T, Miletic G, Miletic V (2006) Loose ligation of the sciatic nerve in rats elicits transient up-regulation of Homer1a gene expression in the spinal dorsal horn. Neurosci Lett 398: 296-299.

Miyabe T, Miletic V (2005) Multiple kinase pathways mediate the early sciatic ligation-associated activation of CREB in the rat spinal dorsal horn. Neurosci Lett 381: 80-85.

Miletic G, Miyabe T, Gebhardt KJ, Miletic V (2005) Increased levels of Homer1b/c and Shank1a in the post-synaptic density of spinal dorsal horn neurons are associated with neuropathic pain in rats. Neurosci Lett 386: 189-193.

Miyabe T, Nishimura R, Mochizuki M, Sasaki N, Mastubayashi K (2001) Chemical restraint by medetomidine and medetomidine?midazolam and its reversal by atipamezole in Japanese macaques (Macaca fuscata). Veterinary Anaesthesia and Analgesia 28: 168-174.